Daptomycin pharmacokinetics may not depend on renal function only and it significantly differs between healthy volunteers and severely ill patients.Herein, we propose a population pharmacokinetics model based on 424 plasma daptomycin concentrations collected from 156 patients affected by severe Gram-positive infections during a routine therapeutic
The unsteady flow field in a reversible pump-turbine is investigated during the continuous load rejection using a 3D computational fluid dynamic analysis.Numerical calculations are carried out using the detached eddy simulation (DES) turbulence model and a new approach involving automatic mesh motion.In this way, the instability of the flow field i
Oxidative stress could be a key selective force shaping the expression of colored traits produced by the primary animal pigments in integuments: carotenoids and melanins.However, the impact of oxidative stress on melanic ornaments has only recently been explored, whereas its role in the expression of AirPods Case carotenoid-based traits is not full
Introduction:Corrosive substance intake, which has an important place in home Electric Hair Tool accidents, is still an important public health problem in our country.In this study, it was aimed to investigate all aspects of patients who applied to the pediatric emergency department with corrosive substance intake in the last decade.Methods:All cas
Objective.To evaluate the effectiveness of a 12-week home-based postal and telephone physical activity and nutrition pilot program for seniors.Methods.The program was delivered by mailed material and telephone calls.The main intervention consisted of a booklet tailored for seniors containing information on dietary guidelines, recommended physical a